歲月麻醉

Anesthesia,Joyful Life
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細胞風暴cytokine storm

細胞風暴是因抑是果?未定之天!

先來複習一下引發細胞風暴的過程,這與正常的免疫反應,只差在controlled or uncontrolled immune response? 而控制『適當』的免疫反應鑰匙是哪一個呢? 抑制免疫反應是汲水救火,還是火上加油?在前兩次流感,SARS, 與禽流感H5N1已經證明大劑量的Steroid是無效的,台大小兒科秉穎醫師持的是反對使用激素的而目前小劑量Steroid尚在擂台上接受挑戰,只是沒有RCT,終究是信者恆信,不信者恆不信,在丁香園內,也有報導使用激素存活的治例,姑且存疑好了!



昨日又有一個案例,是台灣第一個施打疫苗19天後又感染新流感的案例,而且也是出現細胞風暴,這裡有兩點值得關注,一個是施打疫苗後需3~4周才會產生抗體,或者,可能有5%的人施打疫苗後,還是會感染病毒,這個比較沒有爭議;二,是這個病人與劉小弟雖然都是有細胞風暴,但前者顯然與疫苗脫不了關係,而後者又與疫苗關係渺茫,所以,這是一個未解的謎團,
有可能是殊途而同歸,經由不同的機轉,而歸轉到最後相同的路徑,但不管如何,與病毒的侵入脫不了關係。

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