歲月麻醉

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新流感重症的治療選項


前日又聽了疾管局的演講,提到重症患者的治療選項。

  • 克流感加倍劑量
  • human immunoglobulin
  • 痊癒患者的抗體
  • ECMO
其中第三項,香港方面正在進行這方面的工作。Victims' antibodies kill A(H1N1): Study
研究的構想來自Nature的一篇文章:Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors,研究者找到1915年以前出生的人,多數已經高達90高齡的自願者,哇!多感人啊!,總共32人,發現他們的B-cell還可以分泌對抗病毒的抗體,研究人員將這些分泌細胞中,分離出5個monoclone antibody.,都對1918年的病毒有很強的中和作用。
目前所謂新流感H1N1的確認病例,多數為重症的住院患者,這個佔所有感染患者的少數,而多數輕症患者,不是沒到醫院就診,就是只有作快篩試驗,而陽性率偏低下,其中有部份患者會進入rt-RT-PCR,但國內這個檢驗並非特異,只能檢查出來是否是流感A或B,要進一步證實需作進一步特異性的novel H1N1 rt-RT-PCR檢驗,而這個檢驗只有疾管局或主治醫師要求下才會作,因此要想糾合夠數量的志願者,可能尚要費一番前置作業的時間。

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