歲月麻醉

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Procalcitonin 是什麼碗糕?

離開ICU太久了,之前一個M&M的case,在開完刀48小時內死亡,病人有頑固性,持續性的代酸,只看到最後的醫矚是serum procalcitonin,這可是新鮮事喔!查了一下資料!




運用在幾個方面:


  • 細菌性感染與全身性發炎反應
  • 敗血症(Sepsis)與多臟器功能失常綜合症(MODS)
  • 心衰竭休克其他血液循環失調
  • 急性呼吸窘迫症候群(Acute Respiratory Distress Syndrome, ARDS)
  • 自體免疫疾病、慢性非細菌性發炎、其他炎症

而目前新流感的診治中,能發揮什麼樣的功效呢?

最重要的就是要區別病毒性感染還是原發性,繼發性細菌性肺炎。

Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial.JAMA. 2009 Sep 9;302(10):1059-66.

Procalcitonin-based guidelines 的作法是什麼呢?



雖然不能對病患的outcome發揮影響,不過對於減少抗生素的使用與時間,是有正面的效應的。

PSI 與 CURB index 量表:




參考文獻:
1.Luzzani A. Polati E, Dorizzi R, Rungatscher A, et al. 2003. Comparison of procalcitonin and C-reactive proteinas markers of sepsis. Crit Care Med. 31:1737 -1741

2.Antibiotic treatment interruption of suspected lower respiratory tract infections based on a single procalcitonin measurement at hospital admission--a randomized trial.Clin Microbiol Infect. 2009 May;15(5):481-7. Epub 2009 Mar 5.

3.Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial.Lancet. 2004 Feb 21;363(9409):600-7.

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