歲月麻醉

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Intravenous zanamivir

第一個以IV form 治療的個案報告,發表在Lancet,在窮盡 口服oseltamivir 75 mg bid x 5 day, 吸入 zaminivir 15 mg  bid x 7 days後, 使用iv zaminivir 600 mg bid x 7 days 後,奇蹟似的好轉,並痊癒。 不過這同時有給予methylprednisolone 140mg st. and 30 mg/d 的治療,前面 3rd ~10th day 有使用hydrocortisone 50~100 mg/d ,這個劑量似乎是偏低 (200~300 mg/d),這樣的治療,比較雜亂無章,不過可以提供一定的臨床參考,比如,iv form 的抗病毒療效比口服或吸入佳,晚期的抗病毒介入也可以達到預定的療效,而steroid的使用還是無法釐清。


H1N1 pneumonitis treated with intravenous zanamivir.Lancet. 2009 Sep 19;374(9694):1036



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