歲月麻醉

Anesthesia,Joyful Life

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Propofol異丙酚

麻醉藥物proprofol最近因為搖滾天王麥可傑克森的暴斃,突然間成為庶民百姓間關心談論的焦點,propofol在麻醉界可說集三千寵愛於一身的一代絕色,雖有小瑕疵,但瑕不掩瑜,就讓我們來談談這位美姑娘吧!


隨著麥可傑克森(Michael Jackson)死亡原因漸漸明朗,是由異丙酚(Propofol)這種麻醉劑與多種鎮靜藥物混合,造成麥克死亡的主因。自從麥可死訊曝光以來,美國有許多病患害怕使用異丙酚來麻醉,讓美許多醫生需要大費周章保證藥物的安全。....摘自自由時報



Propofol自問世以來,已經超過20年,它可以說麻醉歷史上一個世代的里程碑,因為它的發明,TIGA(total iv general anesthesia),以至於次世代的TCI(Target control infusion),都因它的出現,而得以實現。

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Soybean Allergy 大豆過敏


麻醉藥裡面含有soybean,也是TCI麻醉最有名的組成麻藥 - propofol。它的出現,不僅僅是多了一種hyponotics,而且改變了麻醉的整個面貌,它具有起效快,恢復短,清醒品質高的特點,而其缺陷,注射疼痛,與過敏,正是它的賦型劑excipient - soybean oil,扯的後腿。

這星期的NEJM,提到兩個使用含有soybean oil 的generic drug (PPIs) -omeprazole (一種時下最流行治療消化潰瘍的藥物)引起過敏的案例。Hypersensitivity to Generic Drugs with Soybean Oil NEJM Volume 361:1317-1318 eptember 24, 2009 Number 13

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